London. A significant percentage of chronic lymphocytic leukemia (CLL) cases present a particularly aggressive progression resistant to treatment. Tesearchers of the Clinical-Experimental Oncohematology of the National Cancer Institute of Aviano (Pordenone), directed by Valter Gattei, identified one of the main causes are mutations in the NOTCH1 gene. Their finding was published in journal “Leukemia”. (9Colonne)
